Vascularly Perfused Rat Small Intestine: A Research Model for Drug Absorption
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چکیده
منابع مشابه
Absorption of benzoic acid in segmental regions of the vascularly perfused rat small intestine preparation.
Oral bioavailability is a consequence of intestinal absorption, exsorption, and metabolism and is further modulated by the difference in activities among segmental regions. The influence of these factors on the net absorption of benzoic acid (BA), a substrate that is metabolized to hippurate and is transported by the monocarboxylic acid transporter 1, was studied in the recirculating, vascularl...
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To assess the digestion and assimilation of gelatin and gelatin hydrolysates, the in situ absorption of typical hydroxyproline-containing dipeptides, Pro-Hyp, Hyp-Gly, Ser-Hyp Ala-Hyp, and pentadecapeptide, (Pro-Hyp-Gly)(5), was investigated in the rat small intestine. During vascular perfusion after the injection of Hyp-Gly, Pro-Hyp and (Pro-Hyp-Gly)(5) into the jejunum, peptide-form Hyp but n...
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Intestinal edema remains a serious clinical problem, and novel approaches to study its pathophysiology are needed. It was our aim to develop a long-term stable isolated perfused rat small bowel preparation permitting analysis of vascular, luminal, interstitial, and lymphatic compartments and to demonstrate the utility of this model by studying the effects of the proinflammatory mediator platele...
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Digoxin, a substrate of P-glycoprotein (Pgp) and cytochrome P450 3a (Cyp3a), was used to illustrate the inductive effects of pregnenolone-16 -carbonitrile (PCN), a ligand of the pregnane X receptor, on the absorption and disposition of [H]digoxin in the vascularly perfused rat small intestine preparation. Although increased Cyp3a protein was observed with Western blotting analysis after PCN tre...
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Digoxin, a substrate of P-glycoprotein (Pgp) and cytochrome P450 3a (Cyp3a), was used to illustrate the inductive effects of pregnenolone-16alpha-carbonitrile (PCN), a ligand of the pregnane X receptor, on the absorption and disposition of [3H]digoxin in the vascularly perfused rat small intestine preparation. Although increased Cyp3a protein was observed with Western blotting analysis after PC...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1980
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)31492-1